Alpha 1-antitrypsin deficiency
Alpha 1-antitrypsin deficiency (?1-antitrypsin deficiency A1AD) is a genetic disorder that causes defective production of alpha 1-antitrypsin (A1AT) leading to decreased A1AT activity in the blood and lungs and deposition of excessive abnormal A1AT protein in liver cells. There are several forms and degrees of deficiency principally depending on whether the sufferer has one or two copies of the affected gene because it is a co-dominant trait.
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