Meningococcal disease

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Meningococcal disease or Meningococcemia is an acute and potentially life-threatening infection of the bloodstream. Meningococcal disease describes infections caused by the bacterium Neisseria meningitidis (also termed meningococcus). It carries a high mortality rate if untreated. While best known as a cause of meningitis widespread blood infection (sepsis) is more damaging and dangerous. Meningitis and meningococcemia are major causes of illness death and disability in both developed and under developed countries worldwide.The disease's pathogenesis is not fully understood.

What are the symptoms of Meningococcal disease?

There may be few symptoms at first. Some may include:

  • Anxiety
  • Fever
  • Headache
  • Irritability
  • Muscle pain
  • Nausea
  • Rash with red or purple spots (petechiae)

Later symptoms may include:

  • Changing level of consciousness
  • Large areas of bleeding under the skin (purpura)
  • Shock

What causes Meningococcal disease?

Meningococcemia is caused by a bacteria called Neisseria meningitidis. The bacteria frequently lives in a person's upper respiratory tract without causing visible signs of illness. The bacteria can be spread from person to person through respiratory droplets -- for example, you may become infected if you are around someone with the condition when they sneeze or cough. Family members and those closely exposed to someone with the condition are at increased risk. The infection occurs more frequently in winter and early spring.

Who is at highest risk?

The bacteria can be spread from person to person through respiratory droplets -- for example, you may become infected if you are around someone with the condition when they sneeze or cough. Family members and those closely exposed to someone with the condition are at increased risk. The infection occurs more frequently in winter and early spring.

When to seek urgent medical care?

If you feel you are developing symptoms of meningococcemia, contact your doctor.

Diagnosis

Blood tests will be done to rule out other infections and help confirm meningococcemia. Such tests may include:

  • Blood culture
  • Complete blood count with differential
  • Clotting studies (PT, PTT)

Other tests that may be done include:

  • Lumbar puncture to obtain spinal fluid sample for CSF culture
  • Skin biopsy and gram stain
  • Urinalysis

Treatment options

Meningococcal disease is a medical emergency. Persons with this type of infection are often admitted to the intensive care unit of the hospital, where they are closely monitored. The person may be placed in respiratory isolation for the first 24 hours to help prevent the spread of the infection to others. Treatments may include:

  • Antibiotics given through a vein (IV), given immediately
  • Breathing support
  • Clotting factors or platelet replacement -- if bleeding disorders develop
  • Fluids through a vein (IV)
  • Medications to treat low blood pressure
  • Wound care for areas of skin with blood clots
Links
https://en.wikipedia.org/wiki/Meningococcal disease
Relevant Occupations
Emergency Medicine Specialist
Paediatric Emergency Medicine Specialist
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