Hereditary nonpolyposis colorectal cancer
Lynch syndrome (HNPCC or hereditary nonpolyposis colorectal cancer ) is an autosomal dominant genetic condition that has a high risk of colon cancer as well as other cancers including endometrium (secondary most common up to 50%) ovary stomach small intestine hepatobiliary tract upper urinary tract brain and skin. The increased risk for these cancers is due to inherited mutations that impair DNA mismatch repair. It is a type of cancer syndrome.
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