Amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS)—also referred to as motor neurone disease (MND) and sometimes referred to as Lou Gehrig's disease in the United States—is a neurodegenerative disease with various causes. It is characterised by rapidly progressive weakness due to muscle atrophy and muscle spasticity difficulty in speaking (dysarthria) swallowing (dysphagia) and breathing (dyspnea). ALS is the most common of the five motor neuron diseases.